Effects Of Lipoproteins And Triglycerides On Heart Disease
Low Density Lipoproteins , the “Bad” Cholesterol
The main villain in the cholesterol story is low-density lipoprotein . Heart disease is least likely to occur among people with the lowest LDL levels. Lowering LDL is the primary goal of cholesterol drug and lifestyle therapy.
Low-density lipoprotein transports about 75% of the blood’s cholesterol to the body’s cells. It is normally harmless. However, if it is exposed to a process called oxidation, LDL can penetrate and interact dangerously with the walls of the artery, producing a harmful inflammatory response. Oxidation is a natural process in the body that occurs from chemical combinations with unstable molecules. These molecules are known as oxygen-free radicals or oxidants.
In response to oxidized LDL, the body releases various immune factors aimed at protecting the damaged arterial walls. Unfortunately, in excessive quantities they cause inflammation and promote further injury to the areas they target.
High Density Lipoproteins , the “Good” Cholesterol
High density lipoprotein appears to benefit the body in several ways:
- It removes cholesterol from the walls of the arteries and returns it to the liver for disposal from the body.
- It helps prevent oxidation of LDL.
- It may also fight inflammation.
Low Hba1c May Also Increase Mortality
Increased mortality was also reported for HbA1c levels below the optimal range in diabetics. Some reported an increased risk for heart disease or death among nondiabetic subjects with HbA1c levels below 4.0% , 4.8% , 4.9% or 5.0% .
Some explanations for the low HbA1c and mortality relationship, include: being underweight or malnourished, inflammation, anemia, high alcohol consumption, liver disease and chronic kidney failure .
It appears that malnutrition, inflammation, and functional decline are characteristics shared by the populations that showed increased mortality and low HbA1c. Thus, frailty or decline may be the main confounding factor explaining the relationship between increased mortality risk and low HbA1c .
In one study, where HbA1c < 5% was associated with adverse outcomes in nondiabetic people, a link to inflammation and autoimmunity was suggested .
When To See A Doctor
A person with diabetes should see their doctor regularly to monitor and manage their diabetes.
They may also wish to consult a doctor who specializes in treating new or worsening fatigue that interferes with daily life.
People should seek medical attention for fatigue that occurs alongside other symptoms, such as fever, chills, or malaise, as these could indicate an infection.
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What Causes High Cholesterol If I Eat Healthy Can It Be Genetic
If you eat a healthy diet and get regular exercise but still have high cholesterol, your DNA may be a bigger factor than your lifestyle. About 1 in 250 people in the United States live with familial hypercholesterolemia , a life-threatening inherited disorder that causes high cholesterol.
Unfortunately, 90 percent of people who have it dont know it, according to the FH Foundation, a national nonprofit organization based in Pasadena, California. Screening for high cholesterol is the only way to identify people who have FH. Because of this, all children should have a cholesterol screening once between ages 9 and 11, recommends the American Academy of Pediatrics.
If your LDL is above 100, its already considered high. If its higher than 190, you may have FH, according to leading heart groups, such as the AHA, the American College of Cardiology, and the National Lipid Association. If a parent has FH, their child has a chance of having it, too. Finding out if you have FH and getting treated if you do is vital, because having FH means your risk of heart disease is 20 times higher than that of people who dont have inherited high cholesterol, according to the FH Foundation.
What Are The Risk Factors Of Heart Disease Why Is Lowering Cholesterol Important
High cholesterol is a well-known risk factor for heart disease and stroke. Other risk factors include smoking, an unhealthy diet, lack of physical activity, obesity, high blood pressure, diabetes, and familial hypercholesterolemia, among others.
Too much cholesterol in the blood increases the risk of heart attack and stroke. In people with high cholesterol, the cholesterol builds up in the walls of the blood vessels, causing them to become narrow. This process is called atherosclerosis. When the arteries become narrow, blood flow to the heart muscle is reduced or blocked. This cardiovascular event is called a heart attack.
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Living With Metabolic Syndrome
Metabolic syndrome is a lifelong condition that will require changes in your lifestyle. If you already have heart disease or diabetes, follow your healthcare providers recommendations for managing these conditions.
Lifestyle changes involved in managing metabolic syndrome include:
- A healthy diet
- Stopping smoking if youre a smoker or use other tobacco products
- Losing weight if you are overweight or obese
What Are Statins How Do They Reduce The Risk Of Cardiovascular Disease
If you have high cholesterol levels on your blood tests, your doctor may prescribe statins to lower your cholesterol. The treatment can help to reduce your stroke and heart disease risk and improve your cardiovascular health.
Statins work by blocking a substance that the liver needs to make cholesterol. This leads to the reduction of the cholesterol amount in the blood, thus reducing the risk of cardiac events.
While these drugs are highly effective and safe for most people, they can cause side effects.
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What Supplements Help Adrenal Fatigue
There are several categories of supplements that can help to treat adrenal fatigue. They should be used in combination with lifestyle changes like avoiding stress, improving diet, and getting more sleep.
There are a few basic nutrients that are particularly important for supporting the adrenal glands and HPA axis, especially during times of stress. These include vitamins B5, B6, and B12, vitamin C, and magnesium. Omega-3 fatty acids, CoQ10, and probiotics can also be tremendously supportive during this time.
Herbal supplements can be useful for regulating cortisol levels and moderating the stress response. These include ashwagandha, licorice, Rhodiola rosea, Siberian ginseng, and maca.
For the best results, discuss your supplementation with your healthcare professional. Here is some more information on supplements for adrenal fatigue.
What Are The Warning Signs Of High Cholesterol
High cholesterol typically doesnt have any symptoms until it is an emergency event. The only way to know if you have a high level of ldl cholesterol is through a blood test. Leaving cholesterol untreated can lead to the buildup of plaque over time, damaging the heart and putting you at risk for a heart attack or stroke. Keep an eye out for heart attack or early stroke symptoms like:
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Maybe Shes Born With It
High cholesterol due to genetics is called familial hypercholesterolemia . People with FH are born with high cholesterol because their bodies cant process LDL correctly.
FH is one of the most common inherited diseases, affecting 1 in 220 adults. People with FH have a 13 times greater risk of heart disease. Untreated FH can result in chronically high cholesterol levels and heart disease.
Signs And Symptoms Of Low Red Blood Cell Count
Fatigue or tiredness is the most common of all symptoms associated with having a low red blood cell count. This is due to the lack of hemoglobin within the blood since this iron-rich protein is found in your red blood cells and carries oxygen throughout the body.
Other symptoms of a low red blood cell count may include dizziness , shortness of breath, headaches, pale skin, chest pain, and coldness in the hands or feet.
When there arent enough red blood cells in your body to carry hemoglobin, your heart has to work even harder so the lower amount of oxygen in your blood can be moved. This may lead to heart failure in severe cases or less serious issues such as an enlarged heart, a heart murmur, or irregular heartbeats .
Complications of Low Red Blood Count
When you have a low red blood cell count, your blood has a reduced capacity to carry oxygen and its viscosity is also reduced. Your blood is therefore thinner and can move more quickly because of the lack of resistance among the bodys blood vessels. This in turn causes more blood to flow through your heart in a single minute than typically does, known as increased cardiac output. The blood also carries less oxygen so your blood vessels dilate, further reducing resistance and increasing the speed of blood flow.
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Optimal And Normal Range
Lab results are commonly shown as a set of values known as a reference range, which is sometimes referred to as a normal range. A reference range includes upper and lower limits of a lab test based on a group of otherwise healthy people.
Your healthcare provider will compare your lab test results with reference values to see if any of your results fall outside the range of expected values. By doing so, you and your healthcare provider can gain clues to help identify possible conditions or diseases.
In Europe, the whole urea molecule is measured, whereas in the United States only the nitrogen component of urea is measured .
The BUN is roughly one-half of the blood urea .
Normal human adult blood should contain between 5 to 20 mg of urea nitrogen per 100 ml of blood, or 1.8 to 7.1 mmol urea per liter .
To convert from mg/dL of blood urea nitrogen to mmol/L of urea, multiply by 0.357.
The range is wide because of normal variations due to protein intake, protein breakdown, state of hydration, liver urea production, and urea elimination by the kidneys .
What Causes Cardiovascular Disease
Cardiovascular disease is a broad term that includes a variety of heart and blood vessel conditions, such as coronary artery disease, peripheral arterial disease, heart attack, stroke, high blood pressure, heart valve disease, vascular disease, aorta disease, heart failure, cardiomyopathy, abnormal heart rhythms, congenital heart disease and many other heart and blood vessel conditions.
The most common cause of cardiovascular disease is atherosclerosis. Atherosclerosis is the build-up of cholesterol and fatty deposits on the inner walls of the arteries that restricts blood flow to the heart .
Without adequate blood, the heart becomes starved of oxygen and the vital nutrients it needs to work properly. This is called ischemia. Ischemia causes symptoms of heart disease, such as chest pain or angina and when one or more of the coronary arteries becomes completely blocked, a heart attack can occur.
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What Is Dizziness Actually
We come across the term dizziness all the time, or we often feel dizzy, but have you ever wondered what it is actually? Dizziness is a term that refers to an array of sensations such as feeling woozy, faint, unsteady, or weak. Sometimes people feel like their surroundings are spinning around them and say theyre dizzy, but in fact, thats just a form of dizziness called vertigo. Lightheadedness is one of the most common reasons why people schedule an appointment to see their doctor or health care provider.
It is worth noting that dizziness is not a standalone disease or health condition, but rather a symptom that occurs due to a wide range of health problems. Thats exactly why dizziness is not something you should ignore. Multiple diseases can make us feel dizzy, but your doctor can make an accurate diagnosis and find the root cause.
Genetic Factors And Family History
Genetics can play a major role in determining a person’s blood cholesterol levels. Genes may influence whether a person has low HDL levels, high LDL levels, high triglycerides, or high levels of other lipoproteins, such as lipoprotein. There are several types of inherited cholesterol disorders.
FH is a genetic disorder that causes high cholesterol levels, particularly LDL, and premature heart disease. There are two forms of FH:
- Heterozygous FH, in which the genetic mutation is inherited from one parent, occurs in about 1 in 500 people. It increases the risk for heart attack between the ages of 40 to 60.
- Homozygous FH, in which the genetic mutation is inherited from both parents, is much rarer. It occurs in about 1 in 1 million people. People who have homozygous FH are at risk for having extremely severe hypercholesterolemia, many experiencing heart attack or death before the age of 30.
Familial lipoprotein lipase deficiency is a group of rare genetic disorders that causes depletion of the enzyme lipoprotein lipase. This enzyme helps in the removal of lipoproteins that are rich in triglycerides. People who are deficient in lipoprotein lipase have high levels of cholesterol and fat in their blood.
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Can High Cholesterol Cause Erectile Dysfunction
High cholesterol alone is not thought to cause erectile dysfunction , but plaque-clogged arteries can, because blood flow is essential to an erection, according to the National Institute of Diabetes and Digestive and Kidney Diseases. Too much cholesterol may also affect the bodys ability to produce the hormone testosterone, as well as nitric oxide, which helps relax the penile tissue. Both of these factors can lead to ED as well.
The good news is that in older men with both high cholesterol and ED, taking statins medications used to treat high cholesterol is associated with a significant improvement in ED, according to research presented at the American College of Cardiologys 63rd Annual Scientific Session.
Lifestyle Changes To Boost Hdl Cholesterol Levels
Here are the foods you can easily incorporate into your heart-healthy diet to either help lower your LDL cholesterol or boost your HDL cholesterol levels.
Oats: Changing you morning meal might be the simplest way to whittle down your LDL cholesterol . By taking two servings of oats, you can lower LDL by 5.3 percent in only six weeks. Oats contain beta-glucan, which plays a key role in LDL removal and excretion from the body.
Nuts: A study shows that people lowered their total cholesterol by 5.4 percent and LDL cholesterol by 9.3 percent by taking 1.5 ounces of walnuts six days a week for one month. Details of the study can be gleaned from the American Journal of Clinical Nutrition. And just to make it easy for you, 1.5 ounces is about a shot glass and a half.
Tea: Tea contains a lot of antioxidants to fight inflammation. In some cases, it even fights cancer. Not many people know, however, that tea is also a great defence against LDL cholesterol. According to research conducted with the USDA, black tea has been shown to reduce blood lipids by up to 10 percent in only three weeks.
Beans: Researchers at Arizona State University Polytechnic found that adding ½ cup of beans to soup lowers total cholesterol, including LDL, by up to eight percent. The fiber content in beans plays an important role in limiting the absorption of dietary cholesterol.
Making these lifestyle changes can help you boost your HDL cholesterol levels naturally.
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Too Much Cholesterol In The Blood Directly Affects The Heart And May Result In An Increase In Cardiac
Mumbai: Cholesterol is a fatty substance known as a lipid and is vital for the normal functioning of the body. While “good” cholesterol have long known to be beneficial, its excess can also raise your risk of death, researchers claim. Once too much of cholesterol start to accumulate in our body, it becomes a breeding ground for physiology disorders. Too much cholesterol in the blood directly affects the heart and may result in an increase in cardiac-related illnesses. Increasing cholesterol also increases the risk of heart attack.
Here are some of the symptoms which indicate cholesterol increase in the body:
Possible Signs Of Low Cholesterol
Some studies have shown a link between low cholesterol and certain mental health disorders.
- Depression While there are many causes of depression, studies have shown patients with low cholesterol are more prone to depression Researchers do not totally understand the link between depression and low cholesterol, but believe it may be tied to cholesterols role in making Vitamin D. Vitamin D is important for cell growth. If brain cells arent healthy, you may experience anxiety or depression.
- Anxiety Like depression, studies show patients with very low levels of cholesterol had higher rates of anxiety than the general population.
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Understanding Ldl And Hdl Cholesterol
Balancing your cholesterol levels is one of the hardest parts of staying healthy. But that doesnt mean you shouldnt make the effort. Instead, the best way to control your cholesterol is to know everything about it both how it affects your body, and how you can manage it.
Dr. Michael Skardasis and his experienced team at Optimal Performance Medicine strive to provide you with the best information so you can live life at your healthiest. Heres what you need to know about cholesterol so you can support your body in the best way possible.
Overuse Of Stimulants Like Sugar And Caffeine
Are you one of those people whose day revolves around finding your next shot of caffeine? If so, youre not alone! Millions of people rely on stimulants like coffee and sugar to lift them up when they get tired. However, theres a big difference between drinking an occasional coffee and consuming stimulants all through the day.
The problem is that stimulants tend to lose their effectiveness over time. As chronic stress takes its toll on your endocrine system, each cup of coffee or sugary snack gives you less of an energy boost. Caffeine can prevent you from getting a good sleep too. The more stressed and tired you become, the more stimulants you need. This vicious cycle is how many people unwittingly accelerate their decline into hormonal dysregulation and extreme fatigue.
It doesnt have to be this way. Simply becoming more mindful of your caffeine and sugar consumption will often help to reduce it. Limit yourself to one or two coffees each day at first, then try to give it up entirely. Eat a nutritious, healthy diet, and try some of these low sugar recipes. Look for low glycemic fruits instead of sugary dried fruits or fruit juices. Learn how to improve your sleep hygiene so you wont feel the need for those stimulants. And identify ways to work more efficiently during the day, so you take rests when needed.
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