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Fatigue After Pfizer First Dose

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Dr. McGeorge shares experience with second dose of Pfizer COVID-19 vaccine

According to the CDC, someone is considered fully vaccinated two weeks after the second shot of the Moderna and Pfizer vaccines and two weeks after the single dose J& J vaccine.

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We do know that the moment we put the shot in your arm, you effectively have no immunity and then it starts rising from there with all of the shots, said Howard Forman, a professor of public health at Yale University.

Forman said it is important that people dont get a false sense of security immediately after the shot, especially as the majority of Connecticuts towns are under a red alert and variants of the virus continue to spread.

Presumably a lot of the increased cases we are seeing are younger individuals who, for one reason or another, are either partially vaccinated or not vaccinated yet and that is where the spread seems to be occurring, said Forman. Get vaccinated, wait the appropriate time, follow the guidelines.

If you get the Pfizer vaccine, your second dose should be scheduled three weeks after your first dose. For Moderna, your second dose should be four weeks after your first.

The reason for that is that the CDC wants you to follow the same exact schedule that was used in clinical trials, explained Paulo Verardi, a virologist and vaccinologist at the University of Connecticut.

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Table 3 Systemic Reactions In Persons Aged 18

Table 3. Systemic reactions in persons aged 16-55 years, Pfizer-BioNTech COVID-19 vaccine and Placebo

Dose 1
945 266

a Mild: does not interfere with activity moderate: some interference with activity severe: prevents daily activity Grade 4: emergency room visit or hospitalization for severe fatigue, severe headache, severe muscle pain, or severe joint pain.

b Mild: 1 to 2 times in 24 hours moderate: > 2 times in 24 hours severe: requires intravenous hydration Grade 4: emergency room visit or hospitalization for severe vomiting.

cMild: 2 to 3 loose stools in 24 hours moderate: 4 to 5 loose stools in 24 hours severe: 6 or more loose stools in 24 hours Grade 4: emergency room visit or hospitalization for severe diarrhea.

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We need to gather as much data as we can about the impact and any after-effects of COVID-19 vaccines to support the rollout and help end the pandemic.

If youâre not already using it, and use it to record your COVID-19 vaccine, followed by daily health reports to help us monitor the after-effects and impact of vaccination.

You can also register a profile and log reports on behalf of relatives or people you are caring for who may not be able to use the app themselves.

Together weâll get through this. Stay safe and keep logging.

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Pain Around The Injection Site

The Pfizer-BioNTech COVID-19 vaccine is administered in two doses, 3 weeks apart.

To date, safety data on the vaccine has been collected from 37,586 participants enrolled in an ongoing phase 3 clinical trial.

Among those participants, 18,801 have received the vaccine and 18,785 have received a placebo. They have been followed for a median of 2 months following vaccination.

The most commonly reported side effect from the vaccine is injection site reaction. Such reactions can cause some pain and other symptoms around the area where the vaccine is injected.

You sometimes get some redness, some warmth, a little bit of mild swelling or firmness around the site of the injection. Thats very typical, Heinz told Healthline.

It can be a little tender, it can hurt to move the arm a little bit, he continued.

Injection site reactions were reported by

Women Experience More Side Effects

Pfizer Caused This Reaction in Half of Recipients, New ...

In a February study that looked at the data from the first 13.7 million COVID-19 vaccine recipients, the Centers for Disease Control and Prevention found that nearly 80 percent of the people reporting reactions were female, even though only 61.2 percent of the injections had been given to women. In a similar vein, the CDC reported that all anaphylactic reactions to the Moderna shot have been in women 44 of the 47 people whove had these reactions to the Pfizer injection were female.

The majority of people who have experienced the severe blood clotting issues with the J & J vaccine, and also the AstraZeneca vaccine in Europe and the United Kingdom, have been women. There has been speculation about hormones playing a rolewhich is always the first culprit thats looked at when you see a major sex difference, says Penns Wherry.

Several other factors may also contribute to this gender imbalance. Women also seem to have a more robust immune system, both in their innate responses and in their adaptive immune reactions. Females mount a stronger antibody response than males but its a double-edged sword because this is why women have more auto immune disease than men, says Shresta of the La Jolla Institute for Immunology.

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How Many People Experience Pfizer And Moderna Side Effects

Most people may experience at least one side effect after getting their dose the most common being an injection site reaction . In the first few months after the Pfizer and Moderna vaccines were authorized, 70% to 75% of people reported this side effect after getting either dose.

Additionally, 50% of people reported systemic side effects after their first dose, which jumped to about 70% after the second dose.

Chills and fever, which were reported by only about 9% of people after their first dose, went up to about 30% after the second dose. Similarly, joint pain was more common after the second shot, going from about 9% to 26% .

During the Pfizer and Moderna clinical trials, side effects were reported more frequently in younger people getting the vaccine. Below well review a few other factors that might influence your likelihood of experiencing side effects.

Helpful Tips To Relieve Side Effects

Talk to a doctor about taking over-the-counter medicine, such as ibuprofen, acetaminophen, aspirin , or antihistamines for any pain and discomfort experienced after getting vaccinated.

People can take these medications to relieve side effects after vaccination if they have no other medical reasons that prevent them from taking these medications normally. Ask your childs healthcare provider for advice on using a non-aspirin pain reliever and other steps you can take at home to comfort your child after vaccination.

It is not recommended to take these medicines before vaccination for the purpose of trying to prevent side effects.

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The Vaers System Describes Patients Who Experienced Dizziness From The Pfizer Vaccine

CDCSome of the dizziness reports in the CDC database for the Pfizer vaccine.

Some patients experienced dizziness after the first Pfizer shot, as well as the second. Here are some of the reports in the VAERS system that mention dizziness after the first Pfizer shot:

Vertigo/dizziness with nystagmus Abdominal pain & diarrhea Fatigue, muscle and joint aches Fever.

38 hours after vaccination I woke in the middle of the night with extreme abdominal pain, dizziness, and severe diarrhea. This continued for 2 hours. I lost 6 pounds.

Dizziness/felt woozy/light headed Weakness vision changed increased heart rate/heart rate went up slightly had pressure in his head.

Almost immediately after vaccination patient started feeling poorly. Lightheaded, dizzy, just felt weird. Able to drive home but continued to worsen, looking back should not have driven but was not thinking clearly. Feeling terrible once home, throwing up violently.



Mild dizziness followed by jitteriness and heart pounding. Increased blood pressure. Lasting for about 1-2 hours.

Dizzy, tired, weak, nausea, joint pain. I am resting and still feeling the effects. But slowly getting better.

Boosters Haven’t Been Authorized For All Us Adults Yet

Pfizer vaccine less effective after 6 months, study says

US regulators recommend boosters for elderly people because their immunity from vaccines tends to wane more quickly than average. Immunocompromised people, including cancer and HIV patients, as well as those who’ve had organ transplants, may also mount a weaker immune response to vaccines.

But many questions remain about boosters. In addition to the CDC and FDA’s slightly different recommendations, an independent group of advisors to the CDC put forth its own guidelines on Thursday. The group recommended boosters for nursing home residents, people 65 and older, and all adults with underlying medical conditions – but not for healthcare workers, teachers, or prisoners.

Boosting younger adults wouldn’t do much to prevent COVID-19 hospitalizations, the group said. Other experts have similarly argued that there’s no need for the widespread use of boosters yet.

In a review published in The Lancet, 18 scientists warned of potential risks of introducing boosters too frequently or too soon. In particular, the scientists worried that boosters might unnecessarily lead to higher instances of rare side effects like myocarditis, a type of heart inflammation. But Pfizer didn’t record any cases of myocarditis in its booster trial.

“We continue to believe in the benefits of a booster dose for a broader population,” Kathrin Jansen, Pfizer’s head of vaccine research and development, said in a statement.

Hilary Brueck contributed reporting.

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Scheduling Your Second Shot

  • Planning for your second shot is important.
  • If you need help scheduling your vaccination appointment for your second shot, contact the location that set up your first appointment.
  • If you are having trouble or have questions about using a vaccination management or scheduling system, reach out to the organization that enrolled you in the system. This may be your state or local health department, employer, or vaccination provider.
  • Scheduling an appointment for your second shot at the time you get your first shot is recommended, but not required.
  • If you need to get your second shot in a location that is different from where you received your first shot , there are several ways you can find a vaccine provider for your second dose.

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Table 5 Local Reactions In Persons Aged 12

Table 5. Local reactions in persons aged 12-15 years, Pfizer-BioNTech COVID-19 vaccine and placebo

Dose 1
0 0

aMild: > 2.0 to 5.0 cm moderate: > 5.0 to 10.0 cm severe: > 10.0 cm Grade 4: necrosis or exfoliative dermatitis .

bMild: does not interfere with activity moderate: interferes with activity severe: prevents daily activity Grade 4: emergency room visit or hospitalization for severe pain at the injection site.

Pain At The Injection Site Was The Most Common Side Effect Of Pfizer

This Side Effect Is More Common After Your First Pfizer ...

Injection site reactions are common among vaccines and nothing to worry about, according to experts. The study found that 64 and 67 percent of Pfizer recipients reported pain at the injection site after the first and second dose, respectively. Other common injection site reactions following a Pfizer shot included redness, swelling, and itching. The researchers noted that “injection site pain is common after both the first and second doses of either mRNA-based vaccine.” And for more reactions to expect, Be Prepared for This the Night You Get Your COVID Vaccine, Doctors Warn.

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I Got The Covid Vaccine Are My Side Effects Normal

A member of the Philadelphia Fire Department administers the Johnson & Johnson COVID-19 vaccine to a woman at a vaccination site setup at a Salvation Army location in Philadelphia, Friday, March 26, 2021.

This is one of a series of articles in which reporters from WHYYs Health Desk Help Desk answer questions about vaccines and COVID-19 submitted by you, our audience.

Last week, the Food and Drug Administration and the Centers for Disease Control and Prevention recommended a pause in the distribution of Johnson & Johnsons single-dose shot. Thats because six women out of around 6.8 million people who received the vaccine experienced a rare and severe type of blood clot after getting their shots.

The news made a lot of our listeners and readers hypervigilant about their side effects. Heres what you should expect after getting a COVID-19 vaccine.

Why Do I Feel Tired After Getting The Covid Vaccine

It might feel crappy to crash out hard after getting your COVID vaccine, but it’s not actually a bad thing in terms of what’s happening in your body. “When people experience fatigue after a COVID vaccine, itâs usually an indication that our immune system is working,” says Dr. Natasha Bhuyan, M.D., the regional medical director of One Medical. “As our immune system mobilizes cells to fight off the virus in the future, itâs normal for us to feel a sensation of fatigue.”

You may also feel more wiped out after the second shot than you did after the first, and thatâs normal, too. âBecause the body has already started to develop antibodies after your first dose, your body responds more robustly after your second dose and you are more likely to be fatigued or have more pronounced side effects in general,â says Dr. Vivek Cherian, M.D., a Baltimore-based internal medicine physician. So even if the first shotdidnât knock you out, itâs not uncommon for the second to hit you like a truck.

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Are Some People More Likely To Have Side Effects From The Moderna And Pfizer Vaccine

Your immune systems response to the vaccine will depend on your medical history and the type of vaccine. Several factors can affect how your immune system reacts to a vaccine, including:

  • Vaccine formulation

  • The injection site

For example, infants and toddlers are less likely to have reactions at the vaccine injection site but more likely to develop a fever than adults. And in some studies, women were more likely to report side effects to the COVID-19 vaccines than men. Nearly 80% of women reported adverse events versus about 20% of men.

The Most Common Side Effects To Expect After Your Pfizer Booster: Headache Fatigue And Pain At The Injection Site

Preliminary tests show 3rd dose of Pfizer neutralizes Omicron
  • Pfizer’s COVID-19 booster shot yields mild to moderate side effects, much like its second dose.
  • Injection-site pain is the most common, as well as headaches and fatigue.

A third dose of Pfizer’s coronavirus vaccine yields mild to moderate side effects, much like the second shot, according to data released this month by the Food and Drug Administration.

The FDA has authorized a third dose, or “booster,” for people 65 years and older and others at high risk of severe COVID-19. That includes people who are more likely to get sick because of their health status, as well those who are at high risk of exposure due to where they live and work – such as healthcare workers, teachers and daycare staff, grocery store workers, and residents of homeless shelters or prisons.

On Thursday, the Centers for Disease Control and Prevention recommended a booster at least 6 months after the second dose for: People 65 years and older, nursing home residents, and people ages 50 to 64 with underlying medical conditions. The agency said others who might consider a booster include younger adults with underlying medical conditions or those at increased risk of COVID-19 exposure because of their job or living arrangement.

Data from Pfizer shows that protection from its vaccine declines over time, and that a third dose is safe. In its booster trial, participants saw 3.3 times higher antibody levels one month after the booster than one month after their second dose.

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How Many People Have After

Since the roll out of the vaccines in the UK, weâve been asking everyone who gets vaccinated to log their jab, so that we can understand more about the impact of the new COVID-19 vaccines and their effects.

So far, more than a million people have logged their vaccinations with ZOE. Our data team has analysed reports from 282,103 people who have received their first dose of the Pfizer vaccine, and 28,207 whoâve had both.

We found:

  • Around one in eight people who received one dose of the vaccine experienced at least one systemic effect within seven days of their jab, compared with roughly one in three getting the AstraZeneca jab
  • Most symptoms happen in the first two days after vaccination, with headache, fatigue and chills or shivers being the most common
  • Almost one in five of the participants under 55 years old were likely to experience after-effects, compared to around one in ten over 55s
  • Around seven in ten people who received their first dose had at least one local after-effect in their arm, most commonly pain and swelling in the day or two after the jab

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